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Thomas E Hughes Selected Research

CKD732

1/2018Preclinical Efficacy and Safety of the Novel Antidiabetic, Antiobesity MetAP2 Inhibitor ZGN-1061.
12/2017Effects of MetAP2 inhibition on hyperphagia and body weight in Prader-Willi syndrome: A randomized, double-blind, placebo-controlled trial.

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Thomas E Hughes Research Topics

Disease

7Type 2 Diabetes Mellitus (MODY)
01/2011 - 06/2002
5Obesity
01/2018 - 06/2007
3Sickle Cell Anemia (Hemoglobin S Disease)
01/2022 - 10/2020
3B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia)
01/2022 - 01/2018
3Graft vs Host Disease (Graft-Versus-Host Disease)
01/2020 - 07/2014
2Primary Immunodeficiency Diseases
01/2020 - 06/2017
2Prediabetic State (Prediabetes)
01/2020 - 06/2009
2Body Weight (Weight, Body)
01/2020 - 01/2018
2Weight Loss (Weight Reduction)
01/2018 - 12/2017
1Hematologic Neoplasms (Hematological Malignancy)
01/2022
1Chronic Pain
11/2021
1Residual Neoplasm
01/2021
1Bronchiolitis Obliterans Syndrome
01/2020
1Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease)
01/2019
1Retinitis Pigmentosa (Pigmentary Retinopathy)
01/2019
1Neurodegenerative Diseases (Neurodegenerative Disease)
01/2019
1Parkinson Disease (Parkinson's Disease)
01/2019
1Prader-Willi Syndrome (Syndrome, Prader-Willi)
01/2018
1Venous Thrombosis (Deep-Vein Thrombosis)
12/2017
1Hyperphagia (Overeating)
12/2017
1Pulmonary Embolism
12/2017
1Disease Progression
02/2015
1Vomiting
12/2013
1Blast Crisis (Blast Phase)
12/2013
1Diarrhea
12/2013
1Anemia
12/2013
1Leukemia
12/2013
1Nausea
12/2013
1Neutropenia
12/2013
1Thrombocytopenia (Thrombopenia)
12/2013
1BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia)
12/2013
1Neoplasms (Cancer)
03/2012
1Cardiovascular Diseases (Cardiovascular Disease)
06/2009
1Metabolic Diseases (Metabolic Disease)
06/2009
1Fatty Liver
06/2009
1Insulin Resistance
06/2009
1Glucose Intolerance
04/2002

Drug/Important Bio-Agent (IBA)

3Glucose (Dextrose)FDA LinkGeneric
01/2020 - 04/2002
3Dipeptidyl Peptidase 4 (Dipeptidyl Peptidase IV)IBA
06/2003 - 04/2002
2plerixaforFDA Link
11/2021 - 10/2020
2fumagillinIBA
01/2020 - 01/2018
2methionine aminopeptidase 2IBA
01/2020 - 01/2018
2Cyclophosphamide (Cytoxan)FDA LinkGeneric
01/2020 - 06/2017
2Insulin (Novolin)FDA Link
01/2018 - 04/2002
2ibrutinibIBA
01/2018 - 02/2015
2CKD732IBA
01/2018 - 12/2017
2Blood Glucose (Blood Sugar)IBA
06/2009 - 04/2002
1Alemtuzumab (Campath)FDA Link
01/2022
1Hydroxyurea (Hydrea)FDA LinkGeneric
11/2021
1serum P-component (CIt)IBA
01/2021
1ofatumumabFDA Link
01/2021
1Pentostatin (Nipent)FDA LinkGeneric
01/2020
1Busulfan (Busulfex)FDA Link
01/2020
1Proteins (Proteins, Gene)FDA Link
01/2019
1Rhodopsin (Visual Purple)IBA
01/2019
1SynucleinsIBA
01/2019
1Pharmaceutical PreparationsIBA
01/2018
1Methionine (L-Methionine)FDA Link
01/2018
1ZGN-1061IBA
01/2018
1Interleukin-2 (IL2)IBA
07/2014
1Transaminases (Aminotransferases)IBA
12/2013
1Lipase (Acid Lipase)FDA Link
12/2013
1Tyrosine Kinase InhibitorsIBA
12/2013
1bosutinibIBA
12/2013
1fludarabineIBA
03/2012
1Rituximab (Mabthera)FDA Link
03/2012
1Dipeptidyl-Peptidase IV InhibitorsIBA
01/2011
1FatsIBA
06/2009
1Trans Fatty AcidsIBA
06/2009
1Investigational DrugsIBA
06/2009
1elaidic acidIBA
06/2009
1LipidsIBA
06/2007
1Triglycerides (Triacylglycerol)IBA
06/2007
1EnzymesIBA
04/2002

Therapy/Procedure

4Therapeutics
06/2009 - 06/2002
3Hematopoietic Stem Cell Transplantation
01/2020 - 03/2012
2Transplantation
01/2020 - 06/2017
1Blood Component Removal (Apheresis)
11/2021
1Glycemic Control
01/2020
1Bone Marrow Transplantation (Transplantation, Bone Marrow)
01/2020
1Caloric Restriction
01/2018
1Stem Cell Transplantation
07/2014
1Drug Therapy (Chemotherapy)
03/2012
1Fat-Restricted Diet (Diet, Fat Restricted)
06/2009